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  • To avoid this problem, the use of phosphorylated adaptors is a simple solution that would favor the representation of both alternatively spliced transcripts that formed the heteroduplex structure.ERBB2, or HER-2/neu, is an oncogene that is over-expressed in 20-30% of human breast carcinomas and is associated with poor prognosis, independent of the lymph node status [38,39].
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