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  • It is involved in many cellular processes including cell growth, survival, and invasion [32,47,48]. mTOR exist in two complexes mTORC1 and mTORC2 [46,47]. mTORC2 phosphorylates Akt at S473 allowing phosphoinositide-dependent kinase 1 (PDK1) to phosphorylate Akt at T308 [47].
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