age (1-fold to 2-fold); neonatal intensive care unit admission (1-fold to 2-fold); major congenital malformations, particularly cardiac and musculoskeletal malformations (2-fold to 3-fold); chromosomal anomalies in IVF-ICSI (1-fold to 2-fold); and a probable increased risk of genetic imprinting disorders such as Beckwith-Wiedemann and Angelman syndromes.