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  • proteins such as channels and other transporters are usually under-represented in databases like PDB. Based on a seminal work from the 1980s that demonstrated that the structure is more conserved than the sequence (Chothia and Lesk, 1986; Chothia et al., 1986), new methods to produce molecular models based on reference structures have been developed (Sali and Blundell, 1993; Sali et al., 1995; Sa
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