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  • The recent multicentre, prospective controlled cohort study mentioned above followed 295 pregnancies exposed to PPIs, including 53 exposed to pantoprazole, and compared pregnancy outcomes with those of 868 control subjects.6 Rate of major congenital malformations in the pantoprazole group was 2.1% (1/48) compared with 3.8% in the control group (30/792).
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