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  • STAT3 upregulation of TIMP-1 provides a clear illustration of a gene up regulated by STAT3 but may support or suppress tumor growth depending on the context in which it is expressed.Another example of a gene that is primarily up regulated by STAT3 but may support or suppress tumor growth is JunB. As mentioned above, JunB is in the family of Jun proteins that make up the AP-1 transcription factor.
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