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  • The precise sites of linker histone binding to the nucleosome remain in dispute, but there is evidence, mainly from in vitro analyses, arguing both for (Ball et al., 1983; McArthur and Thomas, 1996) and against (Campoy et al., 1995; Nightingale and Wolffe, 1995; Hashimshony et al., 2003) a role of DNA methylation in linker histone binding.
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