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  • Nitric oxide synthases (NOS) produce NO by the oxidation of a nitrogen atom of l-arginine to NO, using O2 and reducing equivalents provided by NAD(P)H as substrates. iNOS, the form of NOS most associated with antimicrobial activity, is primarily regulated at the transcriptional level and can be stimulated by the presence of microbial products and cytokines such as TNF??, IL-1 and IFN-?? (Vazquez-T
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