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  • FMRP is an RNA binding protein that contains two KH domains and one Arg-Gly-Gly (RGG) RNA binding domain, and binds to a number of localized transcripts, including MAP1b, PSD95, and its own mRNA. Binding is thought to occur in part through recognition by the RGG domain of a stem ???G-quartet??? loop in the target mRNA. FMRP is transported into dendrites in a neuronal activity-dependent manner, ass
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