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  • In cases where R5 is H, one may treat 6-chloroanthranilic acid (II) with triazine in a suitable solvent, such as EtOH, in the presence of a suitable base such as piperidine, preferably while heating at about the reflux temperature of the solvent to provide the quinazolinone VIII (R5=H). to obtain compounds where R5 is not H, one may react the amide IX with an acid chloride R5 COCl, in a suitable s
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