In patients who have nonpurulent cellulitis (and no abscess), use of trimethoprim-sulfamethoxazole alone to target MRSA is problematic, since S. pyogenes is a common pathogen and this organism typically responds poorly to trimethoprim-sulfamethoxazole.[15] Thus, in patients who have nonpurulent cellulitis without abscess, the initial regimen should include an agent, such as amoxicillin, amoxicilli