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  • Increasing evidence is pointing to the role of COX-2 and its products, notably prostaglandin E2, in the development of NMSC. Overexpression of COX-2 has been revealed in various neoplasms ranging from colorectal cancer to breast cancer, as well as skin cancer [1,2].Normal skin has minimal levels of COX-2 and PGE-2, with levels of COX-2 increasing in correlation with the severity of skin tumors fro
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