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  • Similarly, ad-ministration of the two drugs 1 day apartdid not give rise to the same symptoms.However, rechallenge with the twodrugs with the original protocol againled to cholinergic toxicity.These symptoms are typical of theacute syndrome experienced by somepatients treated with irinotecan alone (2)and suggest that an interaction is occur-ring between the two drugs, with ox-aliplatin potentiatin
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