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  • In autoimmune diseases such as Multiple Sclerosis (MS), ROI have been implicated as mediators for demyelination and axonal damage [5,6], and enhanced respiratory burst activity has been detected in leukocytes of MS patients compared to control individuals [7].One of the key enzymes leading to production of ROI is the leukocyte NADPH oxidase, consisting of several subunits, which are membrane-bound
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