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  • In addition, CD4+ T cells mediate cytolysis, whereas CD8+ T cells induce similar DTH. 12,13 CD8+ T cells also regulate the activation and differentiation of CD4+ cells, the development of CD4 perforin-mediated cytotoxicity, suppress CD4 proliferative responses, and influence other components of the immune response such as eosinophil recruitment, macrophage activation, and antibody production by B
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