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  • In addition to its crit-ical role in the regulation of early inflammatory respons-es and promotion of the Th1-type repertoire, preclinicalstudies have suggested that IL-12 is an effective anti-can-cer agent against various experimental malignancies.Work in numerous murine models has demonstratedthat the anti-tumor effects of IL-12 are primarily medi-ated via the induction of IFN-?? secretion by T
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