Microcapsules present a core-shell structure with a liquid core surrounded by a polymer shell.Commonly used materials and their derivatives for preparing micro- and nanoparticles bifurcate natural materials including chitosan, gelatin, alginate, and other materials and synthetic materials, such as PLA(polylactide), PLGA(poly(lactic-co-glycolic acid)), PCL(polycaprolactone), and other synthetic one