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  • In contrast, a M. tuberculosis mutant defective in a nitrate reductase required for hypoxic growth in vitro was not attenuated in vivo [8].In the fungal kingdom, some pathogens, such as Candida albicans, are capable of anaerobic fermentation in rich medium, but even in these species, molecular oxygen is thought to be essential for synthesis of ergosterol, NAD, and heme, molecules likely to be scar
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