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  • In contrast, cytokines such as interleukin (IL)-4, IL-13 and IL-10 promote the maturation of alternatively activated M2 macrophages.8,9 The M2 phenotype promotes tumor survival by favoring proliferation and tumor progression,10 as well as by stimulating angiogenesis and lymphangiogenesis.11 M2 macrophages promote extracellular matrix remodeling12 while at the same time regulating a complex chemoki
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