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  • In their classic paper, Brinkman et al noted that ???unsolved is the question whether human hemoglobin is changing from one form to the other, or whether there are 2, originally different forms (eg, the resistant fetal type and the adult form).???3 Much has been learned since that time, including the structure and sequence of both the ??- and ??-globin loci9???12 (Figure 1), the transcriptional re
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