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  • In other embodiments, the average size of the hyaluronic acid is greater than about 200 kDa, 300 kDa, 400 kDa, 500 kDa, 600 kDa, 700 kDa, 800 kDa, 900 kDa, 1000 kDa, 5000 kDa, 10,000 kDA. [0094] It is generally preferred that a maximum dose of the hyaluronic acid, analog, or other agent that binds to the hyaluronic acid binding region of CD44 (alone or in combination with other therapeutic agents)
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