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  • In neuroinflammatory diseases such as multiple sclerosis, human immunodeficiency virus (HIV) encephalitis and spinal cord injury, the disruption of the blood-brain barrier (BBB) by MMP, especially MMP-9, is considered to be central to the pathogenesis of these diseases.123(a) Multiple sclerosis In multiple sclerosis activated and antigen-specific T-cells, dendritic cells and monocyte/macrophages c
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