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  • Similarly, a binding element's N-terminus can be engineerd to include a reactive group for attachment to the support surface. [0063] E. Coupling to Substrates/Linkers [0064] Methods of coupling the binding element to the reactive end groups on the surface of the substrate or on the linker include reactions that form linkage such as thioether bonds, disulfide bonds, amide bonds, carbamate bonds, ur
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