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  • Differential screening eventually revealed the presence of a second, inducible cyclooxygenase, called prostaglandin endoperoxide synthase-2 or Cox-2. 16,17 Induction of this isoform by several mediators, including proinflammatory cytokines, such as interleukin (IL)-1, tumor necrosis factor (TNF), interferon ??, endotoxin, growth factors, or shear stress implied a function for Cox-2 in both inflamm
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