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  • Finally, mice lacking LKB1, a tumor suppressor which directs cell polarity and when mutated, produces epithelial cancers, show markedly increased VEGF (47, 48).The present study addresses breast tumor epithelial organization and VEGF production, but it is important to note that other components of the tumor microenvironment, including fibroblasts and macrophages, are also rich sources of angiogeni
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