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  • Risk factors such as anemia, female gender, age, and renal function9 have been identified, but the rates of bleeding have not changed significantly using the traditional femoral approach; however, recent data from the ACUITY trial10 showed that the use of vascular closure devices was independently associated with lower rates of access-site bleeding (odds ratio, 0.78; 95% CI, 0.61???0.99; p = 0.04)
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