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  • Without wishing to be bound by theory and as stated above, one of the mechanisms by which a selective COX-2 inhibitor may lead to an enhancement in the effectiveness of the compound of formula (I) to function as an anti-tumour agent is by the capacity of the selective COX-2 inhibitor to affect the plasma pharmacokinetics of the compound of formula (I) which may cause an increase in the bioavailabi
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