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  • VDR is constitutively expressed in APC, such as macrophages and DC, and is inducible in activated T lymphocytes [9???11].Several studies have demonstrated immunosuppressive effects of vitamin D3 on the functions of DC. In vitro maturation of both human and mouse DC in presence of vitamin D3 lead to reduced expression of MHC-II and the costimulatory molecules CD40, CD80, and CD86 resulting in an en
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