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  • Thus, in AJ mouse livers, there is a rapid adaptation of several metabolic pathways to HFD: 1) increased peroxisomal ??-oxidation; 2) increased n-3 and n-6 fatty acid detoxification by desaturation and conversion to bioactive, protective lipids such as 2-AG; and, as shown in the current study, 3) increased OxPhos and
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