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  • Six of the proteins, including clusterin, neuron-specific enolase, and vascular cell adhesion molecule 1, predicted 19.5% of hippocampal volume in subjects with MCI, while seven, including brain-derived neurotrophic factor and plasminogen activator inhibitor-1, predicted 11.9% of hippocampal volume in those who had AD. The researchers also examined the relationship between the proteins and disease
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