Typically, the infectionspreads to a lymph node from a skin, ear, nose, or eye infection or fromsuch infections as infectious mononucleosis, cytomegalovirus infection,streptococcal infection, tuberculosis, or syphilis.The infection may affectmany lymph nodes or only those in one area of the body.Symptoms and DiagnosisInfected lymph nodes enlarge and are usually tender and painful.