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  • An important paralog of this gene is IL1RL2.UniProtKB/Swiss-Prot: IL1R1_HUMAN, P14778Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAPto form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation ofNF-kappa-B, MAPK and other pathways.
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