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  • Probably, the leading hypothesis is that the uAUGs attenuate translation by diverting scanning ribosomes from the authentic sAUG. Kozak (2,19) noticed that mRNAs coding for regulatory proteins often contain multiple uAUGs in the 5???-UTRs and proposed that this is an adaptation to prevent excessive and deleterious production of proto-oncogenes, transcription and growth factors, and other proteins
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