Treatment of such patients may require more prolonged treatment, or antimicrobial agents other than doxycyline, amoxicillin, cefuroxime, or intravenous ceftriaxone.DIAGNOSIS OF LYME DISEASE IN PATIENTS WITH PERSISTING OR RELAPSING SYMPTOMSThere are patients who are not aware of any tick bite or any rash, who present with an illness consisting of a combination of symptoms, but without objective sig