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  • Pro-inflammatory cytokines, such as IL-1??, IL-6, and TNF-??, leads not only to immunologic exhaustion, but also renders CD4+ T cells more susceptible to direct HIV infection by enhancing the expression of the HIV coreceptor CCR5.53 Despite the pro-inflammatory cytokines detected in cultures from the aged groups, IL-10 was the highest produced cytokine in these cultures in response to TT. In our p
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