Target genes include growth factors such as vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) (Khachigian et al., 1995; Liu et al., 2003), as well as genes involved in the differentiation of hematopoietic cells (Collins et al., 2008; Laslo et al., 2006) and in neuronal development (Mager et al., 2008; Nagarajan et al., 2001).