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  • Thelevels of p19ARF, p53, and other cell cycle regulators wereexamined on days 0 and 6 after drug selection (Figure 1C).p19ARFand p53 expression was induced by RasV12to a similarextent in wild-type cells and C/EBPb?/?cells. p16INK4aandp21CIP1levels were also increased comparably in wild-typeand C/EBPb?/?cells (Figure 1C and data not shown).Therefore, the inability of C/EBPb?/?MEFs to undergoRasV12
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