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  • The actual binding of the bivalent IgG POM2, however, is a result of the cooperative interaction of each paratope of the IgG molecule with two ??? either consecutive or intermittent ??? epitope stretches within the octarepeat region of PrP. This translates in an apparent binding strength that is much higher and is the most probable reason why POM2 and POM12 are among the most sensitive antibodies
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