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  • The nitrogenous bases of the double helix are paired in specific combinations : A with T and C with G. It was mainly by trial and error that Watson and Crick arrived at this key feature of DNA. At first Watson imagined that the bases paired like with like, for example A with A and C with C. But this model did not fit the X-ray data, which suggested that the double helix had a uniform diameter. ???
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