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  • Thus, serum viral load is the most reliable indicator in predicating the development of HCC. HBeAg seroconversion reflects viral mutations in the HBV genome, especially in the precore and core promoter regions[19], and this usually happen during the natural course of chronic HBV infection, possibly caused by cytotoxic T-lymphocyte (CTL)-mediated clearance.Association of HBV genotypes/subgenotypes
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