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  • The results of locally controlled IgA production are to create a simple feedback loop where DCs and epithelial cells drive IgA production until sufficient levels of IgA block microbial invasion [25].T-cells in PPs are conditioned by gut DCs to produce cytokines, such as the transforming growth factor (TGF)-??, which, together with interleukin (IL)-6 and IL-10 produced by DCs, facilitate the prefer
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