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  • This lack of biomarker includes the newly identified specific serological marker for RA ??? antibodies to cyclic citrullinated peptides [7,8] ??? as well as genetic markers [9-12].A number of studies have shown that the expression of individual proteins ??? particularly cytokines such as TNF??, IL-1??, IL-6 and IFN?? [13,14], chemokines like IL-8 and MCP1, as well as matrix metalloproteinases such
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