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  • These include oxidative stress, endoplasmic reticulum stress, deposition of amyloid (ie, insoluble fibrous proteins) in the pancreas, and deposition of ectopic lipid in the muscle, liver, and pancreas [8,9].All of these stressors can be caused by overnutrition, although it has been difficult to determine which mechanisms are the most important in each tissue, or how much they differ between indivi
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