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  • The TNF family cytokines Fas ligand (FasL) and TRAIL (Apo2 ligand) trigger activation of the caspase pathway without concomitant induction of NF-??B. These death ligands are expressed on cytolytic T cells (CTLs), natural killer (NK) cells, and other types of immune cells and are used as weapons for eradication of virus-infected and transformed cells.59,62,63 Various studies using mice with ablatio
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