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  • The availability of cDNA and genomic clones of many of the components of the IFN system including the IFNs, their receptors, Jak and Stat, IRF signal transduction components, and proteins such as PKR, OAS, Mx, and ADAR, whose expression is regulated by IFNs, has permitted the generation of mutant proteins, cells that overexpress different forms of the proteins, and animals in which the expression
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