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  • These data indicate that lack of FoxO1 in ??-cells curtails insulin expression, and renders key ??-cell transcription factors, Nkx6.1, Pdx1, MafA, and Neurog3 (Zhou et al., 2008), insufficient to maintain ??-cell identity.??-cells, islets, and pancreas can de-differentiate and activate expression of mesenchymal markers, such as vimentin and nestin, in vitro (Russ et al., 2011; Zulewski et al., 200
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