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  • The FZD4 gene located in the EVR1 locus encodes a 7-transmembrane receptor belonging to the Wnt ligand-binding Frizzled family,17- 20 which has a pivotal role in various cellular processes including cell fate determination, control of cell polarity, and malignant transformation.17FZD4, together with its coreceptor, the low-density lipoprotein receptor-related protein 5 (LRP5) gene located in the E
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