The term encompasses most pharmaceuticals that are not proteins or nucleic acids. [0087] The term ???sulfhydryl??? means ???SH, and the term ???sulfonyl??? means ???SO2???. [0088] A ???substitution??? or ???substituent??? on a small organic molecule generally refers to a position on a multi-valent atom bound to a moiety other than hydrogen, e.g., a position on a chain or ring exclusive of the memb