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  • Their results indicated that fucoxanthin can regulate pathways, such as MAPK and PI3 kinase/Akt cascades, which are known to have a negative effect on GJIC. They have concluded that fucoxanthin exhibits anti-proliferative activity in SK-Hep-1 cells along with enhanced expression of connexin genes and GJIC. Satomi and Nishino [32] have also observed an increase in expression of connexin 43 and AP-1
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