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  • The first cluster, represented by variants in IL23R, IL12B, PTGER4, JAK2, KIF21B, STAT3 and other genes, was most strongly associated with Crohn's disease, psoriasis and MS. A second cluster, represented by variants in STAT4, IRF5, TNFAIP3, RGS1, CCR1, IL18RAP, IL2-IL21 and UBE2L3, was most strongly associated with celiac disease, RA and SLE. A third cluster, represented by variants in ORMDL3, CLE
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